专利名称：GM-CSF nucleic acid sequences发明人：Jian-Tai Qiu,Wan-Ching Lai,Yong Liang
Chu,Frank Q. Li
申请号：US10188056申请日：20020703公开号：US06809191B2公开日：20041026
摘要：The present invention relates to improved methods for the treatment orprevention of disease with gene therapy or vaccines comprising host optimized GM-CSFnucleic acid sequences. More particularly, the invention provides methods for codonoptimized GM-CSF with enhanced expression and adjuvant activity ex vivo and in vivo. Thepresent invention also provides for methods of optimizing homologous gene expressionex vivo and in vitro or in transgenic animals.
申请人：VAXIM INC
代理机构：Piper Rudnick LLP
代理人：Steven B. Kelber
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